Contraindications
The use of EXCEDE 200 is contraindicated in animals previously found to be hypersensitive to the drug.

The use of EXCEDE 200 is contraindicated in animals with known allergy to ceftiofur or to β-lactam (penicillins and cephalosporins) group antimicrobials. Due to the extended exposure in horses, based on the drug’s pharmacokinetic properties, adverse reactions may require prolonged care.

Cautions
Administration of EXCEDE 200 into the arteries of the ear of cattle is likely to result in sudden death to the animal.

Cattle: Do not administer EXCEDE 200 at any site other than in the subcutaneous tissue at the base of the ear. As with other parenteral injections, localized post-injection bacterial infections may result in abscess formation. Attention to hygienic procedures can minimize their occurrence. Subcutaneous injection in cattle can cause a local tissue reaction that may result in trim loss of edible tissue at slaughter.

Horses: The administration of antimicrobials to horses under conditions of stress may be associated with acute diarrhea that can be fatal. If acute diarrhea is observed, additional doses of EXCEDE 200 should not be administered and appropriate therapy should be initiated. Due to the extended exposure in horses, based on the drug’s pharmacokinetic properties, adverse reactions may require prolonged care.

EXCEDE 200 is slowly eliminated from the body, with approximately 17 days needed to eliminate 97% of the dose from the body. Animals experiencing adverse reactions may need to be monitored for this duration of time. The use of ceftiofur has not been evaluated in horses less than 4 months of age and in breeding, pregnant, or lactating horses. Persistent muscle stiffness and injection site swelling may occur (see Adverse Reactions). The long term effects on injection sites have not been evaluated.

Warnings

• Treated cattle must not be slaughtered for use in food for at least 13 days after the latest treatment with EXCEDE 200.
• No milk withholding time is required when the drug is used according to the label directions.
• In cattle, administration by unapproved routes such as subcutaneous in the neck, intramuscular, or intramammary may lead to illegal residues.
• Do not use in horses intended for food.
• Do not use in veal calves. The withdrawal period has not been established in pre-ruminating calves.
• To limit the development of antimicrobial resistance:
• EXCEDE 200 should not be used as a mass medication.
• EXCEDE 200 should only be used for treating individual animals as per the indications. The choice of EXCEDE 200 as the most appropriate treatment should be confirmed by clinical experience supported where possible, by pathogen culture and drug susceptibility testing.
• The extra-label use of EXCEDE 200 is not recommended.
• Penicillins and cephalosporins can cause allergic reactions in sensitized individuals. Topical exposures to such antimicrobials, including ceftiofur, may elicit mild to severe allergic reactions in some individuals. Repeated or prolonged exposure may lead to sensitization.
• Avoid direct contact of the product with the skin, eyes, mouth and clothing. Sensitization of the skin may be avoided by wearing latex gloves. Persons with a known hypersensitivity to penicillins or cephalosporins should avoid exposure to this product. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. If allergic reaction occurs (e.g. skin rash, hives, difficult breathing) seek medical attention.

KEEP OUT OF REACH OF CHILDREN.