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Hydroxyzine Pamoate Capsules may be used in the treatment of allergies and may help reduce itching due to skin conditions. Hydroxyxine Pamoate is an antihistamine that may be used to relieve itching that is caused by allergies, flea bite dermatitis, and atopy. It may also be prescribed for its sedative qualities. Provides relief from itching associated with allergies, hives, and rashes. Hydroxyzine Pamoate works by blocking the action of histamine in the body. Histamine is the chemical responsible for many of the symptoms seen when an allergic reaction occurs. Hydroxyzine Pamoate also depresses activity of the central nervous system and is also used to treat anxiety disorders and tension in stressful situations.